ATP Science Block E3 - Body Shaping Serum
Block E3 is one of our favourites from the transdermal range, purely because its so unique in function! The active ingredients work synergistically to tackle estrogen dominance at the site by blocking aromatase activity. Increased aromatase activity will increase estrogen and lower testosterone and increase the activation of the mainly proliferative estrogen receptors to induce fat cell production in localised tissues. It also works to improve the overall appearance of the isolated pockets of fat that love to cling to us for dear life on areas such as the Hips, Thighs, buttocks, arms, stomach and for men Gynecomastia.
Block E3 – Body Shaping Serum
Block E3 is a shaping cream specifically formulated to estrogen dominant fatty areas (pictured below). The net result is:
an improved appearance of regional fat deposits that cause gynaecomastia in men (‘man boobs’)
an improved appearance of isolated pockets of fat on hips and buttocks in women and men
a secret weapon used by bodybuilders and physique models for pre-comp sculpting
a specifically formulated cream for tightening, smoothing and firming unsightly fat deposits
THE EFFECTS OF ESTROGEN DOMINANCE INCLUDE:
increases fat deposits and accumulation in isolated regions (pictured below)
the creation of an estrogen dominant body shape (pictured below)
an increased inter-muscular fat thereby reducing muscle definition
a reduced muscle mass and decrease muscle fibre size
ESTROGEN BODY SHAPE
As estrogen is fat soluble, it is stored in the subcutaneous fat in the following areas:
breasts and chest
backs of the arms
Estrogen Dominance in Men
Raised intracellular oestradiol levels in men, induce and promote obesity, gynaecomastia (man boobs), metabolic syndrome, type two diabetes, benign prostatic hypertrophy and prostate cancer. 2
Estrogen Dominance in women
Elevated estrogen: androgen ratio in women can manifest as changes in body shape that include increased subcutaneous fat on the lower abdomen, buttocks, hips and thighs. Isolated pockets of fat and cellulite on the widest point of the hips are a common sign.
Causes of Estrogen Dominance in men and women
increased aromatase activity, converting testosterone to estrogen
reactive toxins and Xeno-estrogens (from petrochemicals, plastics, Bisphenol A (BPA), pollutions, pesticides)
certain foods that contain high levels of estrogen (e.g. milk)
medications that cause hypogonadism and have anti-androgenic effects (such as the contraceptive pill)
Estrogen Dominance Causes a Vicious Cycle
One of the key features of estrogen dominance is that it can be a self-perpetuating vicious cycle that can be isolated from the rest of the body. This means that the normal regulation and hormonal modulation pathways can sometimes not be able to control it or even be aware that it is happening in localised areas. Estrogen generated in fat cells and breast tissue is predominately used locally and not transported around the body and therefore does not necessarily activate negative feedback mechanisms and triggering subsequent reduction in estrogen production. The net result means you could be making estrogen without your body realising you already have too much of it in certain tissues.
Aromatase Converts Testosterone to Estrogen
Testosterone is metabolised to oestradiol by aromatase, in the cytoplasm of adipocytes, breast cells, endothelial cells and prostate cells, to increase intracellular oestradiol concentration at the expense of testosterone.
Increased aromatase activity will increase estrogen and lower testosterone and increase the activation of the mainly proliferative estrogen receptors to induce fat cell production in localised tissues.
Block E3 for site specific action.
Block E3 contains 3 effective synergistic ingredients to combat estrogen dominance. Block E3 is designed to work locally on regional fat deposits and breast tissue and not systemically. Block E3 is specifically designed to work on isolated pockets of fat and breast tissue.
BLOCK E3 CONTAINS THE FOLLOWING ACTIVE INGREDIENTS.
Oroxylum indicum (Midnight Horror)
Fucus vesiculosus (Bladderwrack)
Piper nigrum (Black Pepper) Essential Oil
Oroxylum indicum (Midnight Horror)
Estrogen receptor blocker
Midnight horror contains Chrysin and Baicalein
Midnight Horror (Oroxylum indicum) is an extremely potent and natural source of the powerful flavones Chrysin (5, 7-dihydroxyflavone, or 5, 7-dihydroxy-2-phenyl-(9CI)) and Baicalein. Midnight horror is an aromatase inhibitor and estrogen blocker.
The flavones Chrysin and Baicalein inhibit the activity of aromatase (CYP19), thus decreasing estrogen biosynthesis and producing anti-estrogenic effects. Baicalein also blocks estrogen receptor activity. Chrysin only works transdermally
Flavones such as Chrysin have very poor oral bioavailability, less than 5% of an oral dose can get past first pass metabolism and digestive tract. Flavones can however be efficiently absorbed when applied to the skin.
Fucus vesiculosus (Bladderwrack)
Exerts anti-estrogenic effects
Inhibits the binding of oestradiol to estrogen receptors
Antioxidant, anti-allergic and anti-inflammatory
Possesses anti-aging activities for skin; improving dermal collagen integrity and elasticity.
Inhibits glycation, which is damage to protein structures caused by binding and oxidation of sugar.
Bladderwrack is an estrogen blocker
Many scientific papers have discussed and studied the Asian diet its association with lower incidences of estrogen related cancers. Researchers have always surmised it to be due to the soy, seafood and green tea. More recently researchers have been led to believe it may actually be due to the kelp and its iodine content they consume regularly and use as part of cosmetics and skincare.
Bladderwrack is an estrogen receptor blocker
Bladderwrack is a potent source of iodine and other compounds including fucoidan and fucophlorethols, which have demonstrated powerful anti-estrogen properties. 3 Bladderwrack extract inhibits the binding of oestradiol (E2) to estrogen receptor alpha and beta. 2 Bladderwrack is also an aromatase inhibitor. Phloroglucinol derivatives, belonging to the class of fucophlorethols, isolated from bladderwrack have been shown to be potent aromatase inhibitors. 5
Bladderwrack is a rich source of beneficial iodine
Bladderwrack is a rich source of Iodine, which has important functions in breast tissue in men and women. Iodine helps to maintain normal breast tissue architecture and function and low iodine produces a hyper-estrogenic state. Iodine deficiency alters the structure and function of mammary gland alveolar cells and makes them highly sensitive to stimulation by oestradiol.
TOPICAL APPLICATION OF THE ACTIVE INGREDIENTS
One of the great challenges in medicine is getting the drug/nutrient/herb to the area where it is needed. E3 Blocker deals with this by delivering its active ingredients straight to where it is needed. As mentioned, taking some agents orally isn’t the best way to take them. Here at ATP Science we take this problem seriously and have developed products like Block E3 which directly targets the area. See the graphic below on how our products get to where they are needed.
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